Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

LI Shi-Hong; JIANG Shan; HE Ming; GUAN Yong-Jing; DONG Ke-Jun; WU Shao-Yong; YUAN Yuan; MI Sheng-Quan; LIU Shu-Tian; YUAN Jian

Chinese Physics C> 2005, Vol. 29> Issue(12) : 1210-1213

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Department of Nuclear Physics,Chinese Institute of Atomic Energy,Beijing 102413,China

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Abstract：
For determining numbers of ⁴¹Ca labeled biological samples, the analytical method of ⁴¹Ca/⁴⁰Ca by Accelerator Mass Spectrometry (AMS) using CaF₂ target was developed at the Beijing HI-13 AMS system. ⁴¹Ca in the biological samples and ⁴¹Ca standard samples were prepared to CaF₂ with a more effective chemical separation and purification procedure. In the ⁴¹Ca AMS measurement, CaF₃^－ negative ion was extracted from ion resource, 7⁺ charge state of particles was chosen after carbon foil stripping and accelerated at 8.5MV terminal voltage. ⁴¹Ca ions were finally recorded by an 140mbar P10 gas filled multi-anode ionization chamber detector. The results showed that ⁴¹Ca and the main isobar, ⁴¹K could be clearly identified in the two-dimensional density spectra, and the interference of ⁴¹K to ⁴¹Ca was eliminated with the very low ⁴¹K counting rate. The absolute measured values of 4 standard samples with ⁴¹Ca/⁴⁰Ca in the range of 1.785×10^－8—1.750×10^－10 were in good linear relationship with the standard values (r²=0.997). After normalized with the 1.785×10^－8⁴¹Ca/⁴⁰Ca standard, the measured values of S2 and S4 standard samples were in good agreement with the nominal values, however, the measured value of S3 deviated the nominal value largely. The ⁴¹Ca/⁴⁰Ca of the biological blanks were estimated below 8.2×10^－13.

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LI Shi-Hong, JIANG Shan, HE Ming, GUAN Yong-Jing, DONG Ke-Jun, WU Shao-Yong, YUAN Yuan, MI Sheng-Quan, LIU Shu-Tian and YUAN Jian. Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target[J]. Chinese Physics C, 2005, 29(12): 1210-1213.

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Received: 2005-03-04
Revised: 1900-01-01

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沈阳化工大学材料科学与工程学院沈阳 110142

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Corresponding author: LI Shi-Hong,

Department of Nuclear Physics,Chinese Institute of Atomic Energy,Beijing 102413,China

Received Date: 2005-03-04
Accepted Date: 1900-01-01
Available Online: 2005-12-05

Abstract: For determining numbers of ⁴¹Ca labeled biological samples, the analytical method of ⁴¹Ca/⁴⁰Ca by Accelerator Mass Spectrometry (AMS) using CaF₂ target was developed at the Beijing HI-13 AMS system. ⁴¹Ca in the biological samples and ⁴¹Ca standard samples were prepared to CaF₂ with a more effective chemical separation and purification procedure. In the ⁴¹Ca AMS measurement, CaF₃^－ negative ion was extracted from ion resource, 7⁺ charge state of particles was chosen after carbon foil stripping and accelerated at 8.5MV terminal voltage. ⁴¹Ca ions were finally recorded by an 140mbar P10 gas filled multi-anode ionization chamber detector. The results showed that ⁴¹Ca and the main isobar, ⁴¹K could be clearly identified in the two-dimensional density spectra, and the interference of ⁴¹K to ⁴¹Ca was eliminated with the very low ⁴¹K counting rate. The absolute measured values of 4 standard samples with ⁴¹Ca/⁴⁰Ca in the range of 1.785×10^－8—1.750×10^－10 were in good linear relationship with the standard values (r²=0.997). After normalized with the 1.785×10^－8⁴¹Ca/⁴⁰Ca standard, the measured values of S2 and S4 standard samples were in good agreement with the nominal values, however, the measured value of S3 deviated the nominal value largely. The ⁴¹Ca/⁴⁰Ca of the biological blanks were estimated below 8.2×10^－13.